Across the street at the north end of the palace, is the Piazza Monteoliveto with its Fountain and the church of Sant'Anna dei Lombardi.
The palace was commissioned by the nobleman Ferdinando Orsini, who acquired lands from the nearby Santa Chiara.
From there it passed to private hands and to the Bourbon monarchy, and became government offices, till becoming part of the University.
The tall windows rise on a marble cornice, and are separated by Piperno rock pilasters with mixed doric-corinthian capitals.
The ensemble breaths an elegant sobriety akin to that of contemporary palaces in Rome, such as the Palazzo Vidoni Caffarelli.