It stands aside from the Cathedral of Sant'Agata, and across the piazza from the Palazzo degli Elefanti, which houses city hall.
In this period a building for training clerics existed adjacent to a Benedictine Monastery in this area, built against the medieval walls of Catania.
In 1757, the institution received a large endowment by Salvatore Ventimiglia, prince of Belmonte, and vicar general to Sicily, which allowed the seminary to grant professors of classical languages, theology, philosophy, mathematics and natural sciences[4] as well as the addition of a publishing house.
Today it still houses the offices of the treasurer of the city, as well as the Museo diocesano di Catania (Museum of the Diocese).
Like the Palazzo Tezzano found in Piazza Stesicoro, this palace has the distinct contrast between the white stone from Ipsica, and a dark plaster colored with volcanic sand.