Palm River-Clair Mel is a census-designated place (CDP) in Hillsborough County, Florida, United States.

The census area includes the unincorporated communities of Clair-Mel City and Palm River.

Palm River-Clair Mel is located just west of the geographic center of Hillsborough County at 27°55′41″N 82°22′44″W / 27.92806°N 82.37889°W / 27.92806; -82.37889 (27.928150, -82.378900),[5] or approximately 6 miles (10 km) southeast of downtown Tampa.

The CDP is bordered to the north and west by the city of Tampa, to the east by Brandon, to the southeast by Riverview, and to the south by Progress Village.

U.S. Route 301 forms the eastern edge of the CDP, running north to East Lake-Orient Park and south to Riverview.