The 1909 structure was destroyed by fire in 1957, and after a vote that narrowly defeated establishing a regional high school, additions were made to the building in 1958 and 1961.

[10] The Palmyra High School Panthers[2] compete in the Freedom division of the Burlington County Scholastic League (BCSL), a sports association operating under the jurisdiction of the New Jersey State Interscholastic Athletic Association (NJSIAA) that is comprised of public and private high schools in Burlington, Mercer and Ocean counties in Central Jersey.

[19] The Palmyra High School football stadium was built by the Works Progress Administration in 1936 and was renovated to include lighting.

[21] The boys' basketball team won the 1956 Group II state title, defeating runner-up Roselle Park High School by a score of 59-38 in the tournament final.

[22][23] The baseball team won the Group I state championship in 1973, defeating Cedar Grove High School in the tournament final.

[25] The team was the 2009 State Group I co-champion with Jonathan Dayton High School after the title game ended in a 0-0 tie.

[28][29] The girls' basketball team won the 2007 South Jersey, Group I state sectional championship with a 46-37 win over Wildwood High School in the tournament final.

[31] The girls soccer team won the 2022 South Jersey Group I title, defeating Audubon High School in the tournament final by a score of 4-1 at the Palmyra stadium.