[1][2] The polyps of Palythoa are partially embedded in an encrusting mat of tissue (coenenchyme) covering the substrate on which the colony grows.

Their colors are also highly variable, with relatively dull shades like cream, coffee, white, brown, or yellow, being the most common.

The presence of this toxin is of significance to aquarists who keep reef aquariums, as Palythoa and related zoanthids are commonly kept as decorative specimens in marine aquaria.

[6] A 2010 study found that a single specimen of Palythoa from a sample of fifteen colonies purchased from three aquarium stores in the Washington D.C. area contained high levels of palytoxin, indicating that toxic individuals are present in the captive population.

However, it is generally recommended to always wear appropriate protective gloves and goggles when reaching into aquaria and handling animals which are suspected to be toxic.