The biggest moment of Panargiakos's history is their participation as a South Group champion in the 1957 Pan-Hellenic Championship with ten teams: from Athens to Panathinaikos, Apollonas and Panionios, from Piraeus to Olympiakos, Ethnikos and Proodeftiki, from Thessaloniki Aris and PAOK and the champions of the North Group, Doxa Dramas.

In the same season (2007–08) they won the championship in the 7th group of the 4th National Division and the Cup of EPC of Argolida, achieving a treble.

In August 2012, for the first time in the history of the club, a second team is formed, the newly established Panargiakos who originated from academies of the wider region and compete in the A'2 category championship.

The team's jerseys have been previously worn by veterans of the First National Division such as Georgios Donis, Dimitrios Kapetanopoulos, Bledar Kola and Andreas Bonovas.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.