Pano-Tacanan (also Pano-Takana, Pano-Takánan, Pano-Tacana, Páno-Takána) is a proposed family of languages spoken in Peru, western Brazil, Bolivia and northern Paraguay.

There are two close-knit branches, Panoan and Tacanan (Adelaar & Muysken 2004; Kaufman 1990, 1994), with 33 languages.

Migliazza has presented lexical evidence in support of a genetic relationship between the Panoan and Yanomaman languages.

[1] Jolkesky (2016) also notes that there are lexical similarities with the Arawakan languages due to contact.

[2] Below is a list of lexical cognates shared between Proto-Pano and Proto-Takana, demonstrating the genetic relatedness of the Pano and Takana branches.