Panserraikos is one of the most important and well-supported clubs in northern Greece and had a near-continuous presence in the First Division in the 1960s and 70s.

The club currently play in Super League Greece, the top tier of Greek football.

Leo of Amphipolis was chosen as the brand that showed the strength and warlike virtues of the people of Serrai.

The dynamics of the newly formed club was huge and so Panserraikos immediately won its promotion to the Alpha Ethniki, finishing first with a difference of 11 points from the second MENT.

In 2008, Panserraikos managed to end a 16-year wait, gaining promotion to the Greek Super League.

On 4 March 2009, Panserraikos won a historic match against Panathinaikos in the Olympic Stadium in Athens for the Greek Cup quarter finals with a score of 3–2 after being up 3–0 for 71 minutes.

Panserraikos finished 5th in 2009–10 Beta Ethniki, but took the 1st place in the play-offs and gained the promotion to the 2010–11 Super League.

Panserraikos finished 8th in 2012–13 Football League, but was relegated to the new amateur 3rd Greek Division due to financial problems, after the death of its chairman Petros Theodoridis and a controversial and unsuccessful attempt by his son Lazaros Theodoridis to sell the club to Russian investor Mr. Konstantin Vostrikov, a self-declared business tycoon who was claiming to construct a 10,000-seat stadium.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.