When he was 10 he was sent to be educated by Andreas Cupicius, a preacher with Protestant leanings, at Weissenkirchen, and served his teacher when he was imprisoned during the persecutions of that time.
The two escaped to Hungary, from where Pantaleon returned to continue his education with Vitus Nuber, abbot of Seisenstein, whom he followed when his patron fled to Germany.
There he came under the protection of Wolfgang, Count Palatine of Zweibrücken, from whom he received a scholarship to Wittenberg University, where he studied for seven years from 1558.
Formerly the church there had been Lutheran, but following the death of Duke Wolfgang it turned to moderate Calvinism, with the support of Pantaleon.
As well as theological and historical works, he wrote much poetry, including the fable collection Centum et quinquaginta fabulae (1604).