Panther Creek is a stream in Polk, Hickory and St. Clair counties of southwest Missouri.
The stream headwaters are in northwest Polk County at 37°46′56″N 93°30′33″W / 37.78222°N 93.50917°W / 37.78222; -93.50917 and the confluence with Brush Creek in southeast St. Clair County is at 37°49′54″N 93°37′41″W / 37.83167°N 93.62806°W / 37.83167; -93.62806.
[1] The stream source lies east of Missouri Route 13 southwest of Humansville.
The stream flows north to northeast and turns westward just south of Flemington and then northwest entering the southwest corner of Hickory County where it passes under Missouri Route 123.
This article related to a river in Missouri is a stub.