In January 1929, five sisters from St. Carolus Borromeus came to Yogyakarta to serve the sick people.

The foundation stone was laid by C.T.M.Schmutzer van Rijckevorsel on September 15, 1928, and the building work was finished in August 1929.

The building was designed by AIA, one of the largest architectural consultants in the Dutch Indies.

The building was similar to St. Carolus Borromeus Main Monastery in Maastricht, the Netherlands.

The hospital is located on Cik Ditiro Street, in front of the main entrance to Universitas Gadjah Mada.