[1] Born in Aosta, De Ceglie joined the Juventus youth system as a schoolboy alongside former teammate Claudio Marchisio[2] and idolized veteran left midfielder Pavel Nedvěd.

[5] When Juventus were relegated to Serie B for the 2006–07 season due to the Calciopoli scandal, De Ceglie and fellow youngsters Claudio Marchisio and Sebastian Giovinco were all promoted to the first team.

He made his senior team debut on 6 November 2006 for Juventus against Napoli, coming on as a substitute for Nicola Legrottaglie after 55 minutes, with the game eventually ending 1–1.

[7] He came on as a substitute for the injured Pavel Nedvěd and made an immediate impact, setting up Amauri's goal to put Juve 3–1 up and forcing a professional foul from Milan right-back Gianluca Zambrotta which resulted in a free kick.

Due to various injury problems, new manager Alberto Zaccheroni named him in the starting line-up more regularly in the latter half of the 2009–10 season.

[13] With the arrival of Antonio Conte, De Ceglie was given the number 11 shirt and a starting place at left-back in the opening game of the 2011–12 season against Parma on 11 September 2011, at the club's new stadium.

He returned to the starting line-up for the Coppa Italia match as a stand-in for Chiellini and the league win against Novara when Bonucci was suspended and set up Simone Pepe's goal just four minutes after kick-off.

[25][28] After becoming a free agent, De Ceglie trained with Benevento,[29] but was not signed by the club ahead of the 2017–18 Serie A season.

[31] After a year and a half as a free agent, in January 2020, De Ceglie joined newly formed club Miami Beach as a player–scout on a three–year contract, becoming the team's first player ever; the role would also see him working with the club's academy, and subsequently take on a position as a director with the team following the end of his contract with the side.

[34] In the summer of 2009, he was called up for the U-21 European Championships held in Sweden, playing in left midfield as Domenico Criscito was preferred at left-back.