Paolo Polidori (4 January 1778 – 23 April 1847) was an Italian cardinal of the Catholic Church.

Paolo Polidori was born in Iesi, Marche; where he studied at the seminary of Perugia.

Polidori was made cardinal priest of Sant'Eusebio in the consistory of 23 June 1834 by Pope Gregory XVI.

Polidori was named titular archbishop of Tarsus on 22 January 1844 and received his episcopal consecration on 11 February.

Polidori died on 23 April 1847 in Rome and was buried in the church of Sant'Ignazio in accordance with his will.