Papegem is a village in the municipality of Lede located in the Belgian province of East Flanders in the Denderstreek.

The Sint-Macharius Chapel was founded in 1890 on account of a typhus epidemic.

In 1958/1959 there was a temporary church built which was received by the inauguration of Macharius as a patron saint.

Before the merger of the municipalities in 1977, Papegem was a residential area of Vlierzele and had no street names.

Every year on the first weekend after the 8 May, there is a 9 day procession in honor of the Holy Macharius with a fair.