Vlierzele is a village on the Molenbeek, in the Denderstreek, at the edge of the Flemish Ardennes, the hilly southern part of East Flanders, Belgium.

It belongs to the municipality of Sint-Lievens-Houtem.

Etymologically the name Vlierzele is derived from Fliteritsale (in 639) and Vliendersele (in 1412).

This is a combination of either the plant name "vlier", which is Dutch for "elder", or the person's name Flether, and "sale" or "sele", which both mean place of residence in Old-Dutch.

[2] The neighbouring villages are: This East Flanders location article is a stub.