The Papel Misionero Natural Cultural Reserve is 45 kilometres (28 mi) from the town of El Soberbio, Misiones.

[2] It would be part of the proposed Trinational Biodiversity Corridor, which aims to provide forest connections between conservation units in Brazil, Paraguay and Argentina in the Upper Paraná ecoregion.

A bill in 2003 proposed that the site be declared of public utility and subject to purchase or expropriation to create a Natural Cultural Reserve under the full control of the province.

In 2011 the owner signed an agreement with the communities to recognise their ownership of 370 hectares (910 acres) of land, which could be cultivated, and for mutual cooperation in conservation.

[7] Mammals include South American tapir (Tapirus terrestris), white-lipped peccary (Tayassu pecari), water opossum (Chironectes minimus), giant anteater (Myrmecophaga tridactyla), greater naked-tailed armadillo (Cabassous tatouay), ocelot (Leopardus pardalis), jaguar (Panthera onca) and black howler (Alouatta caraya).