Papworth St Agnes is a village and civil parish in South Cambridgeshire, England.

The original village can be traced in the settlement remains between existing cottages and the Manor house.

A moat and various earthworks surround the manor but have been disrupted by the road running through the village (a detailed description of the manor building and the earthworks is to be found in "An Inventory of Historical monuments in the County of Cambridgeshire" Volume one).

With the help of the Friends of Friendless Churches, and a great deal of fundraising, the building has been restored and is used for a variety of village activities.

[1] The Rectory, now alienated, is a two-storey building built of white brick for the Rev HJ Sperling in 1847–8 by a builder called John Bland.

It backs onto the meadows that are an area of special natural history interest and which are currently maintained under a scheme of Stewardship.

Aerial maps of the village show ridge and furrow remains of both open field furlongs and old closes in the meadows.

It used to extend to 1,316 acres (5.33 km2), but 18 of these were lost to Papworth Everard during modern boundary adjustments, which came into operation 8 October 1904.

The B1040 on the south-east is part of the county boundary on the south to the Nill Well where it follows the stream north to the Graveley road, and further north to the former county boundary of Huntingdonshire On the east, Ermine Street (A1198) separates Papworth St Agnes from Hemingford Abbots and Hilton.

Nill Well is notable because it is a chalybeate spring meaning the water is impregnated with iron salts The meadows between the brook and to the west of the houses are a conservation area which includes a site of Natural History Interest.

Built of white bricks with a slate roof it occupies a central position in the village.

It had a very tall chimney (it had been shortened since) – possibly to lift the smoke and sparks high above the nearby thatched cottages.