[3] The foundation stone of the new church was laid down on 13 June 1869, on a plot of land donated by the Judge Giovanni Conti.

[5] The titular statue depicting Saint Cajetan was sculpted between 1885 and 1888 by Karlu Darmanin, with the pedestal being made by Giovanni Farrugia and the detachable platform by Antonio Sciortino.

The altarpiece depicts Saint Cajetan receiving the baby Jesus from Mary, and it was painted by the Italian artist Pietro Gagliardi.

Other works of art in the church include paintings by G. Briffa, Raphael Bonnici, Ramiro Calì, Emvin Cremona and other Maltese and Italian artists.

In particular, it draws from the French Gothic style, especially from the Laon Cathedral, and from the Venetian Baroque church of Santa Maria della Salute.

Schinas' original plan was to have a Romanesque turret-like structure similar to those found at Mainz Cathedral and the Basilica of Saint-Sernin, Toulouse, but these would have been alien to the Maltese environment.