Parkesburg is a borough in Chester County, Pennsylvania, United States.

The inn ceased operation as a tavern around 1836 and became Parkesburg's first post office.

In 1872, the Pennsylvania legislature authorized the formation of Parkesburg Borough (from Sadsbury Township).

[5] According to the United States Census Bureau, the borough has a total area of 1.2 square miles (3.1 km2), all land.

9.8% of the population were of Hispanic or Latino ancestry [1] At the 2010 census, the borough was 81.1% non-Hispanic White, 9.0% Black or African American, 0.9% Native American, 0.3% Asian, 0.1% Native Hawaiian or other Pacific Islander, and 2.1% were two or more races.

Pennsylvania Route 10 follows Church Street along a northwest-to-southeast alignment in the eastern part of the borough, while Pennsylvania Route 372 follows Limestone Road and First Avenue along a southwest-to-northeast alignment through the center of town.

Parkesburg is served by the Amtrak Keystone Service regional rail.