The Pathology Transformation Project was initiated by the Strategic Projects Team in an attempt to provide impetus to the Anglian region’s NHS Trusts to transform and consolidate their pathology services in order to realise the required 20% cost savings.

All of the region's pathology laboratory staff, who were originally employed by the Partner Trusts, were required to re-apply for their current positions in the new organisation; the design of the pathology laboratories' staffing structures had been streamlined as part of the intent to realise cost savings.

The Pathology Partnership's head office was based off-site, separate from the Partner Trusts' sites, at the Iconix Business Park in Pampisford.

[citation needed] In April 2015, it emerged that the Pathology Partnership was forecasting a £4.5m deficit for 2014-15 on budgeted income of £67.8m.

[10] The Pathology Partnership formally dissolved at the end of April 2017 with an initial stated debt of £25 million; £20 million of that initial debt was attributable to non-payment of costs to Public Health England, who were subcontracted by the Partnership to deliver the region's Microbiology service.