Many of their descendants were part of powerful local families (for example, Patricio's sister Joaquina was the wife of governor Nicasio Oroño).
Around 1877, popular discontent with the government of Servando Bayo led Oroño (then a national senator) to plot an uprising to regain power, counting with the support of the population of the immigrant colonies.
Cullen led the rebellion in the north, gathering forces and taking control of several towns on his way to the provincial capital.
His second-in-command, Francisco Iturraspe, went before him and attempted to cross the Saladillo Stream from the west, across the pass of Los Cachos, but he was repelled and badly wounded.
[5] Cullen's remains are now buried in the Convent of Saint Dominic in Santa Fe City, next to those of his father and other prominent leaders of the province.