[3] He appeared in the Black Jewel in the Palace episode of Magic Kamison in 2007 and had minor roles in two series, Sine Novela and Zaido: Pulis Pangkalawakan.

[4] The StarStruck 4 cast were then given a show titled Boys Nxt Door, an award-winning youth-oriented situation comedy, in which Avelino played Peter.

[5] In 2008, he appeared in a supporting role in Babangon Ako't Dudurugin Kita, a remake of the 1989 movie of the same title redeveloped by Don Michael Perez and produced by GMA Network.

In 2009, Avelino started a regular stint on GMA's variety show SOP Rules and landed major roles in two series starring Kris Bernal and Aljur Abrenica, fellow Starstruck 4 alumni: Dapat Ka Bang Mahalin?

[29] In 2012, Avelino played Nathan Montenegro in the hit primetime series Walang Hanggan, alongside Coco Martin and Julia Montes.

[32][33] In parallel with his acting career, Avelino began to work on musical projects, beginning with a single, a cover of Restless Heart's "When She Cries".

[42] He starred with Lovi Poe and Jennylyn Mercado in a highly charged erotic-drama romantic comedy film directed by Joel Lamangan, The Bride and the Lover.

[43] He also appeared on a romantic-comedy film directed by Chris Martinez titled Status: It's Complicated, with Jake Cuenca, Solenn Heussaff, Maja Salvador, and veteran comedian Eugene Domingo.

[46][47] 2014: Avelino starred as part of the main cast of Sana Bukas pa ang Kahapon, with Bea Alonzo and Albert Martinez.

He also starred in Give Love on Christmas, it is a Philippine daytime drama anthology series produced by Dreamscape Entertainment Television with KC Concepcion.

FPJ's The Provincial Man; abbreviated as FPJAP and internationally known as Brothers) a 2015 Philippine action drama television series under ABS-CBN Entertainment as one of the guest Antagoinist.

He also top bill the Movie The Unmarried Wife, a 2016 Filipino romance drama film starring Angelica Panganiban, Dingdong Dantes, and himself.

He also top billed the two movies, Kasal a 2018 Filipino romance drama film starring Bea Alonzo, Derek Ramsay and Paulo Avelino.

Directed by Emmanuel Q. Palo and Darnel Joy R. Villaflor, it stars Paulo Avelino, Zanjoe Marudo, Arci Muñoz, Angelica Panganiban and JC Santos.

According to media outlets, despite not having an existing contract with ABS-CBN, Avelino remains a Kapamilya and is set to work on a movie project with Kim Chiu under Star Cinema in 2025.