The following purported languages of South America are listed as unclassified in Campbell (2012), Loukotka (1968), Ethnologue, and Glottolog.
Campbell & Grondona (2012:116–130) lists the following 395 languages of South America as unclassified.
Loukotka (1968) lists the following languages of South America as unclassified.
Divisions A (South) and B (Chaco) (Loukotka 1968: 63): Division C (Central Brazil) (Loukotka 1968: 86–87): Division D (Northeast Brazil) (Loukotka 1968: 92–95): Tropical North Central South America (Loukotka 1968: 165–168): Tropical South Central South America (Loukotka 1968: 178–179): Tropical Central South America (Loukotka 1968: 196–198): Tropical Northeast South America (Loukotka 1968: 228–230): Northern Andean region (Loukotka 1968: 259): South Central Andean region (Loukotka 1968: 272–273): Ethnologue 26 lists the following languages of South America as unclassified: However, Glottolog states that Agavotaguerra is not unclassified, but unattested; the only reports are that the Agavotaguerra speak Yawalapiti.
In addition, Ethnologue classifies Aikanã, Uamué and Xukurú, all of Brazil as isolates, but they are too poorly attested to classify.