Pe Khin was born in Swehman village, Pyawbwe Township, modern day Mandalay Region to A.A. Khan (U Bo Galay) and Daw Toke on 27 August 1912.
[2] He studied Urdu at Swe Hman village Primary School and passed the fourth standard examination.
In January 1946, he attended the first convention of the Anti-Fascist People's Freedom League (AFPFL) as a delegate from the Burma Muslim Congress.
[7] He was the main lobbyist behind a letter by Mandalay leaders requesting that Aung San appoint U Razak for a cabinet post.
[9][10] Aung San and several members of his cabinet were killed while meeting in the Secretariat on 19 July 1947, in an assassination orchestrated by U Saw, a conservative pre-war Prime Minister of Burma.