He was born in Madrid and arrived in the Americas at an early age, in 1714, bound for the Jesuit Reductions of Paraguay.
He also taught at the college in Santa Fe between 1724 and 1730, eventually returning to Córdoba as historian of the Jesuit province of Paraguay.
This work has a detailed map by Father Antonio Machoni, and contains numerous ethnographic details of the peoples of the Gran Chaco, as well as descriptions of the rivers, a study of the types of soil, numerous observations on the flora of the region, and in particular the medicinal plants, and interesting observations on the fauna.
It is a curious fact that Lozano entertained a remarkable opinion of yerba mate: in Historia de la Conquista del Paraguay he writes that it "is the most fitting method to destroy the human type or most wretched nation of the Guarani Indians" .
He died in Humahuaca (in present-day Argentina), and his remains were interred at the church of San Antonio de Padua in the small town of Uquia.