The school opened in the fall of 1972 and graduated its first class in June 1973, with Reynold Peduzzi its first principal and William G. Kuznik serving as Penn-Trafford Superintendent at that time.

[2] The Penn-Trafford School District offers a large variety of clubs, activities and sports.

In keeping with the Native American theme of the two high schools that merged to form Penn-Trafford, Warriors was chosen.

The color-scheme options were selected by the panel to differentiate Penn-Trafford from the other Keystone Conference member schools.

[citation needed] In 2021, Penn-Trafford football won the Pennsylvania state championship in the 5A class.

The band is also a BOA Regional Finalist and a seven-time TOB Class 3 Open Champion.