The road becomes South Water Street and passes residences and a few businesses, crossing a Nittany and Bald Eagle Railroad line and curving to the north.

Past this, the road becomes a divided highway, soon widening to four lanes as it crosses over a Nittany and Bald Eagle Railroad line and comes to an interchange with US 220 Alternate.

The route enters Beech Creek Township and becomes Eagle Valley Road, running past more residences before turning northeast into agricultural areas with some woods and homes.

PA 150 curves to the east and crosses the Bald Eagle Creek, passing a mix of homes and businesses as it heads into the borough of Mill Hall.

The road passes more commercial establishments, becoming the border between Bald Eagle Township to the north and Mill Hall to the south before intersecting the northern terminus of PA 64.

[2][4] The route turns north and narrows to two lanes, crossing the Bald Eagle Creek and briefly running through Allison Township before heading into the borough of Flemington.

At this point, PA 150 turns north-northeast and becomes High Street, a three-lane road with a center left-turn lane that is lined with several homes.

The route continues into more residential areas before entering the commercial downtown of Lock Haven, where it narrows to two lanes and crosses Norfolk Southern's Buffalo Line.

Upon crossing into Pine Creek Township, the route enters more wooded areas and passes through the residential communities of Chatham and Charlton, turning to the east.

PA 150 heads through more rural residential areas before turning south onto Carl Kephart Boulevard and ending at a diamond interchange with the US 220 freeway.