The road heads through more open agricultural areas with some housing developments as it crosses into Walker Township and intersects the northern terminus of PA 550.

The road heads through farmland with some woods and homes as it reaches a junction with the northern terminus of PA 445 in the residential community of Nittany.

[1][2] PA 64 enters Porter Township in Clinton County and runs through more rural residential areas, crossing Fishing Creek before passing through Lamar.

The route intersects PA 477 and heads through a gap in forested Bald Eagle Mountain along with Fishing Creek and the US 220 freeway to the east, crossing into the borough of Mill Hall.

PA 64 turns northwest and becomes South Water Street, passing between homes to the west and the Fishing Creek to the east.