PA 182 is mostly a two-lane undivided road that runs through suburban and rural areas to the southwest of York.

PA 182 heads south into a mix of farms and woods before making a turn east onto Indian Rock Dam Road.

After crossing the York County Heritage Rail Trail and an abandoned railroad line, PA 182 heads farther from the Codorus Creek and enters agricultural areas with some development and woods, crossing into York Township.

The road winds to the east-southeast through more rural areas before entering suburban residential development and crossing George Street.

PA 182 widens into a four-lane divided highway as it passes businesses and reaches an interchange with I-83.