From the state line, the route heads east on two-lane undivided Pierpoint Road through a mix of farmland and woodland.

The road continues through a mix of farms and forests with a few homes, curving to the southeast and crossing Rundelltown Creek west of Norrisville.

The route continues through more rural areas, crossing the Cussewago Creek and passing through Coons Corners prior to reaching an interchange with I-79.

The road runs through rural areas with some residential development prior to crossing the French Creek into the borough of Saegertown and coming to a roundabout with US 6/US 19.

In the southern part of town, PA 198 splits at a roundabout by heading east on South Street, passing under a Western New York and Pennsylvania Railroad line.

PA 198 continues to the residential community of Guys Mills, where it turns east and passes through the Erie National Wildlife Refuge.