Guys Mills is a census-designated place in Crawford County, Pennsylvania, United States.

[3] Guys Mills is located in northwestern Crawford County at 41°37′51″N 79°58′35″W / 41.63083°N 79.97639°W / 41.63083; -79.97639 (41.630787, -79.976325),[4] west of the center of Randolph Township.

According to the United States Census Bureau, the CDP has a total area of 0.15 square miles (0.40 km2), all land.

There were 6.5% of families and 10.9% of the population living below the poverty line, including 17.9% of under eighteens and 12.0% of those over 64.

The John Brown Home, Tannery, & Museum is located in Guys Mills.