PA 226 begins at the Ohio border in Conneaut Township in Erie County, where the road continues west into that state as SR 84.

From the state line, the route heads northeast on a two-lane undivided road through forested areas with some farms and homes.

The road runs through more rural areas as it passes through Tracy.

PA 226 makes a curve to the east as it comes to its eastern terminus at US 6N.

[2][3] The entire route is in Conneaut Township, Erie County.