The route is the designation for the Staff Sergeant Jeremy R. Horton Memorial Bridge that carries Powell Avenue over two railroad lines in Millcreek Township.

In 2011, all of PA 299 was decommissioned except for the Staff Sergeant Jeremy R. Horton Memorial Bridge, and is no longer signed as a traffic route.

The section of Powell Avenue north of the bridge was realigned in 2012 as a result of runway expansion at Erie International Airport.

At the north end of the bridge, the PA 299 designation ends and Powell Avenue continues north as a township-maintained road to Erie International Airport, where the road bypasses the runway to the east as 20th Street and Marshall Drive.

[4][8] In 2011, the entire length of PA 299 with the exception of the Staff Sergeant Jeremy R. Horton Memorial Bridge was removed from the state highway system.