LECOM Health, a non-profit healthcare system serving Erie County and the surrounding areas, also calls the township home.

Evidence exists of Native American presence in Millcreek Township as early as 3700 BC.

As families came they moved from the bayfront settlement of Erie and began to form small hamlets such as Federal Hill, Kearsarge, Marvintown, and Weigelville, all to become part of Mill Creek Township.

As the Erie settlement grew, first into a borough, then a city, it annexed more and more sections of the township.

Built in 1836, mostly by Isabella Nicholson and her sons, it is still owned by the family and is listed on the National Register of Historic Places.

[6] A recurving sandspit peninsula, Presque Isle, connects to the mainland in western Millcreek.

Just west of the entry into Presque Isle was a well-forested area known as Hopkins Grove.

The Erie Electric Motor Company purchased the grove in 1896 for development into an amusement park.

[7] Today, land use in Millcreek is dedicated to retail, commercial and service-oriented businesses, to light industry, public and private schools, and residential areas.