PA 82 heads through rural areas of Chester County along with the communities of Kennett Square, Unionville, and Coatesville.

PA 82 begins as Creek Road at the Delaware state line, where it meets the northern terminus of DE 82, in Kennett Township, Chester County.

From the border, the route winds northwest as a two-lane undivided road through wooded areas alongside the Red Clay Creek.

PA 82 turns west and heads into the borough of Kennett Square, where it becomes East South Street and passes through residential areas.

PA 82 leaves Unionville and continues west on Doe Run Road through farmland with some woods and residences.

[2][3] Upon crossing into West Marlborough Township, the route becomes state-maintained again and continues through more rural areas, curving to the northwest.

The route becomes a four-lane divided highway called Manor Road and winds north along the east bank of the West Branch Brandywine Creek through wooded hills with some development, becoming the border between Coatesville to the west and Valley Township to the east and reaching a partial cloverleaf interchange with the US 30 freeway.

The road crosses the East Branch Brandywine Creek and reaches a junction with the western terminus of PA 282.

The route runs through more farmland and woodland with homes as it comes to an intersection with the southern terminus of PA 345 and Little Conestoga Road in the community of Loag.

At this point, PA 82 turns northwest to remain along Manor Road and heads through agricultural areas with some woods and homes.

The road curves north and becomes South Chestnut Street, coming to a bridge over the Pennsylvania Turnpike (Interstate 76) before a junction with PA 401.

At this point, the route enters the borough of Elverson and runs northeast through residential areas with some fields.

[9][10] Prior to 2008, PA 82 continued north through Elverson on Chestnut Street and entered Berks County.

[13] Over the coming months, local residents got used to the lack of traffic and fought to keep the road permanently closed, forcing PennDOT to forgo any possible bridge replacement.