PA 449 begins at an intersection with US 6 in the community of Walton in Ulysses Township, heading northwest on Brookland Road parallel to the Pine Creek.

From this point, PA 449 turns north and continues through a mix of farmland and woodland in a narrow valley parallel to the Genesee River.

The route runs through more rural areas before intersecting PA 244 in the community of Genesee.

[2] Through Genesee, the road passes homes and businesses, briefly becoming a two-lane divided highway before the intersection with Commercial Street.

At this intersection, PA 449 turns to the west and heads northwest out of Genesee on two-lane undivided North Genesee Street into a mix of farms, woods, and homes.