The route runs through forested areas of hills with some farm fields and homes to the north of the Allegheny River, turning northeast and crossing into Hebron Township.

PA 49 crosses into the borough of Ulysses and passes through more rural areas before turning east onto North Street, running past homes and a few businesses.

PA 49 continues through more rural areas, passing to the south of Northern Potter Junior Senior High School prior to crossing into Harrison Township and becoming an unnamed road.

The route passes through more agricultural areas with some woods and homes, becoming West Main Street and heading into the community of Harrison Valley.

Here, PA 49 runs past homes and turns southeast onto East Main Street, passing more residences along with a few businesses.

[1][2] PA 49 enters Westfield Township in Tioga County and passes through the residential community of Potter Brook before heading through open agricultural areas with a few homes, crossing the Cowanesque River twice and passing south of Cowanesque Valley Junior Senior High School.

The route heads into the commercial downtown of Westfield and intersects the northern terminus of PA 349, becoming East Main Street.

The route passes through agricultural areas prior to entering the borough of Elkland and becoming West Main Street, lined with homes.