Walnut Bottom Road became part of US 11 and PA 13 in 1926, with the latter designation removed two years later.

The road passes through open agricultural areas with occasional patches of woods.

Upon crossing into South Middleton Township, the route turns north onto Allen Road and heads past industrial warehouses.

PA 465 comes to an interchange with I-81 and continues into the borough of Carlisle, passing woods to the west and warehouses to the east.

[5] With the creation of the U.S. Highway System in 1926, US 11 was designated along Walnut Bottom Road, concurrent with PA 13.