The route winds through rural areas of woods with some farms and homes, curving to the northeast.

The route passes through Lashley prior to bending northeast and ascending forested Sideling Hill.

PA 484 curves to the southeast and comes to an intersection with Great Cove Road that provides access to I-70/US 522, at which point there are a few businesses.

The route continues through Warfordsburg prior to turning east onto Piegon Cove Road and passing over I-70/US 522.

The route winds east across forested Cove Ridge, crossing into Thompson Township and coming to its eastern terminus at PA 655.