PA 59 acts as a northerly bypass to US 6, directly connecting Warren and Smethport while US 6 dips south to serve Kane and Mount Jewett.

This highway also serves the U. S. Army Corps of Engineers' Kinzua Dam and LS Power's Seneca Pumped Storage Generating Station.

PA 59 begins at an intersection with US 6 in Mead Township, Warren County, heading east on two-lane undivided Kinzua Road.

[2][3] PA 59 enters Corydon Township in McKean County and continues east through more of the Allegheny National Forest as an unnamed road.

PA 59 comes to its eastern terminus at another intersection with US 6, at which point West Main Street continues east as part of that route.