The highways heads to the northeast, and reaches the eastern terminus at the New York-Pennsylvania border in Damascus Township, where PA 652 crosses the Narrowsburg–Darbytown Bridge over the Delaware River and into New York, continuing as New York State Route 52 (NY 52) and County Route 24 (CR 24) in Sullivan County.

PA 652 progresses northeast as a two-lane local road through Texas Township as the Beach Lake Highway.

Crossing into the village of Bethel, the route winds northeast through Berlin Township and enters Beach Lake.

In Damascus, PA 652 enters a more wooded region of the county until Woodland Drive, where it becomes primarily residential once again.

The route soon bends eastward then to the southeast at Kaiser Street, reaching the Delaware River as it enters Darbytown.

The southern terminus of the route was at the modern US 30/Old Eagle School Road intersection on the Chester–Delaware county line near Devon to the west and Wayne to the east.

[13][14] On March 14, 1972, US 106 was decommissioned and replaced with the PA 652 designation between Indian Orchard and the Delaware River.

It is located about 500 feet (150 m) east of State Route 2011 (Poor Farm Road).

The bridge is 41.99 feet (12.80 m) long and built out of concrete, which handles an average of 6,804 commuters a year.