The road passes through farmland with some trees and homes, crossing the East Branch Big Elk Creek into Londonderry Township.

The route continues east through rural areas and passes near a few residential developments before it intersects PA 796 in the community of Daleville.

Past this intersection, the road curves southeast and parallels PA 41 for a short distance before turning to the east.

The route becomes the border between West Marlborough Township to the north and London Grove Township to the south, passing to the north of a landfill before it continues through more agricultural areas with some woods and homes, intersecting PA 841.

The road continues through rural areas and briefly becomes the border between West Marlborough Township to the north and East Marlborough Township to the south before fully entering East Marlborough Township, where it passes to the north of the University of Pennsylvania's New Bolton Center and crosses the West Branch Red Clay Creek.

The road passes through wooded areas with some fields and residences, crossing into Pocopson Township.

The road continues northeast and runs through a mix of residential developments, fields, and woods.

Past the PA 352 intersection, the road turns north to fully enter Westtown Township, Chester County, passing fields and woods.

The route curves northeast again and crosses into Willistown Township, where it passes through wooded areas of homes.

In 1815, a road was surveyed between Market Street in Philadelphia and McCalls Ferry on the Susquehanna River to facilitate the westward expansion of settlers.