This concurrency was removed by 1930 and the northern terminus of PA 52 was cut back to its current location in West Chester.

From the state line, the route heads north-northwest on two-lane undivided Kennett Pike through wooded residential areas.

The road enters Kennett Township and heads northwest to the community of Mendenhall, where it crosses an East Penn Railroad line at-grade.

Farther northwest, PA 52 comes to an intersection with US 1 (Baltimore Pike) in the community of Hamorton and turns west to form a concurrency with that route, which is a four-lane divided highway that passes fields.

The route passes through areas of woods, fields, and housing developments prior to intersecting West Rosedale Avenue.

The route makes a turn northeast onto Price Street, fully entering West Chester, where it continues through residential areas.

PA 52 ran concurrent with US 122 between West Chester and New Hope by way of Paoli, King of Prussia, Norristown, Montgomeryville, Chalfont, Doylestown, and Buckingham.

[8][9] In 2003, the PA 100 concurrency was removed when the southern terminus of that route was cut back from the Delaware border to north of West Chester.