Pentafluorothiophenol is an organosulfur compound with the formula C6F5SH.

It is a colorless volatile liquid.

The compound is prepared by the reaction of sodium hydrosulfide and hexafluorobenzene.

[1] With a pKa of 2.68, it is one of the most acidic thiols.

[2] Its conjugate base has been used as a ligand in coordination chemistry[3]