Pentalogy of Cantrell (or thoraco-abdominal syndrome) is an extremely rare[1] congenital syndrome that causes defects involving the diaphragm, abdominal wall, pericardium, heart and lower sternum.

[2] Sternal defects too have a range of presentations, from absence of the xiphoid process to shortened or cleft sternum.

If the sternal defect is large enough, the neonate may have ectopia cordis, in which the heart is located outside of the thorax.

Others include atrial septal defect, cardiac diverticulum, pulmonic stenosis, double outlet right ventricle, tetralogy of Fallot, dextrocardia, and transposition of the great vessels.

[4] A 2010 study concluded that the 13th-century Christian saint Rose of Viterbo died of complications of Pentalogy of Cantrell.