From 1930 to late 1933 a massive animated neon advertising sign, featuring a young girl on a swing, hung on West 47th Street in Times Square in New York City.

Today Pepsodent is a "value brand" marketed primarily in discount stores and retails for roughly half the price of similarly sized tubes of Crest or of Colgate.

The product was discontinued in South Africa in 1974 but was revived in 1976 with a new ad slogan "Gets Your Teeth Their Whitest" featuring celebrity endorsers Rita Moreno, Steve Lawrence, and others.

During the thirties and forties, the company sponsored Amos N Andy, and The Pepsodent Show Starring Bob Hope that began airing in 1938 and ran for approximately 10 years on NBC.

The show featured Bob Hope and his cast of regular characters such as Jerry Colonna, Barbara Jo Allen as Vera Vague, singers including Frances Langford and Doris Day, and bandleader Skinnay Ennis.

Famous Hollywood guest stars such as Cary Grant, Orson Welles, Judy Garland, Bette Davis, Humphrey Bogart, Paulette Goddard, Dorothy Lamour, Rita Hayworth, Penny Singleton, Arthur Lake, Basil Rathbone, Gary Cooper, Veronica Lake, Ginger Rogers, Edward G. Robinson, Hedda Hopper, and many more would be on hand to trade comedic barbs with Hope.