Perryville High School is a comprehensive public high school located in the fringe town of Perryville, Arkansas, United States.

[2] Perryville High School is accredited by the Arkansas Department of Education (ADE).

The assumed course of study follows the ADE Smart Core curriculum, which requires students complete at least 23 units prior to graduation.

Students complete regular coursework and exams and may take Advanced Placement (AP) courses and exam with the opportunity to receive college credit.

The Mustangs compete in football, volleyball, golf (boys/girls), basketball (boys/girls), baseball, softball, track and field (boys/girls), and cheer.