Persimmon Run is a 1.69-mile-long (2.72 km) 1st order tributary to the West Branch Christina River in New Castle County, Delaware in the United States.

Persimmon Run rises on the Big Elk Creek divide in Cecil County, Maryland and flows southeast then northeast into New Castle County, Delaware meet the West Branch Christina River at Anvil Park, Delaware.

Persimmon Run drains 1.77 square miles (4.6 km2) of area, receives about 46.2 in/year of precipitation, has a topographic wetness index of 503.39 and is about 21.7% forested.

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