Peyrolles-en-Provence (French pronunciation: [pɛʁɔl ɑ̃ pʁɔvɑ̃s]; Occitan: Peiròla de Provença) is a commune in the Bouches-du-Rhône department in the Provence-Alpes-Côte d'Azur region in Southern France.

Part of the Aix-Marseille-Provence Metropolis, it is located 18 km (11.2 mi) northeast of Aix-en-Provence.

In 2018, Peyrolles-en-Provence had a population of 5,125.

On average, Peyrolles-en-Provence experiences 59.3 days per year with a minimum temperature below 0 °C (32.0 °F), 0.8 days per year with a minimum temperature below −10 °C (14.0 °F), 0.4 days per year with a maximum temperature below 0 °C (32.0 °F), and 66.8 days per year with a maximum temperature above 30 °C (86.0 °F).

The record high temperature was 44.4 °C (111.9 °F) on 28 June 2019, while the record low temperature was −14.1 °C (6.6 °F) on 12 February 2012.