Phenyl-2-nitropropene

[7][8][9] In the pharmaceutical industry, P2NP is used to produce a racemic amphetamine mixture, branded under the trade names Adderall and Mydayis, amongst others.

Different reducing agents commonly lithium aluminium hydride (LAH), sodium borohydride, aluminum amalgam or Raney nickel are used in suitable solvents like isopropyl alcohol or tetrahydrofuran.

The above diagram depicts P2NP reduction to amphetamine by either LAH, sodium amalgam, Raney nickel, or palladium used as catalysts.

One in which phenyl-2-nitropropene is reduced to phenyl-2-nitropropane using sodium borohydride, followed by hydrolysis of the nitro group with hydrogen peroxide and potassium carbonate to produce phenylacetone (1-phenyl-2-propan-2-one).

This anion nucleophilically adds to the aldehyde forming a β-nitro alcohol, which is subsequently dehydrated to yield the nitroalkene.

Often, primary amines like n-butylamine, methylamine, and ethylamine are used as catalysts, as is anhydrous ammonium acetate at times.

Reduction of P2NP to Amphetamine
Synthesis of phenyl-2-nitropropene